Role of Tumor Necrosis Factor Alpha, Interleukin 8 and Dexamethasone in the FAK Expression by Human Nucleus Pulposus Cells / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
;
: 40-47, 2006.
Article
in Korean
| WPRIM
| ID: wpr-66465
ABSTRACT
PURPOSE:
Human nucleus pulposus cells from intervertebral disc specimens were cultured to study the effects of TNF-alphaand IL-8 on the FAK expression by these cells. The effect of co-stimulation with dexamethasone on the FAK expression by nucleus pulposus cells was also studied. MATERIALS ANDMETHODS:
The FAK expression in cultured human nucleus pulposus cells relation to TNF-alpha, IL-8 and dexamethasone was assessed by performing western blot.RESULTS:
The activated FAK expression was up-regulated by treatments of TNF-alpha and IL-8. Dexamethasone attenuated the cytokine-induced FAK expression. The effects of inflammatory cytokines on the FAK expression were found to be concentration dependent with greater correlation shown by IL-8 than by TNF-alpha.CONCLUSION:
The FAK expression of human nucleus pulposus cells was up-regulated by TNF-alpha and IL-8 stimulation and it was attenuated by the co-administration of dexamethasone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dexamethasone
/
Blotting, Western
/
Cytokines
/
Interleukin-8
/
Tumor Necrosis Factor-alpha
/
Focal Adhesion Protein-Tyrosine Kinases
/
Intervertebral Disc
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Orthopaedic Research Society
Year:
2006
Type:
Article
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