Experimental Study on the Effect and Mechanism of Water Extract of Red Ginseng on Asthmatic Mice with Airway Inflammation / 医学研究杂志

ABSTRACT

Objective To investigate the effect and mechanism of water extract of red ginseng on asthmatic mice with airway inflammation.Methods Totally 75 BALB/c mice were selected,they were divided into normal group (Physiological saline equivalent),model control group (Physiological saline equivalent),low dose group (Water extract of red ginseng,100mg/kg),high dose group (Water extract of red ginseng,100mg/kg) and positive control group (Dexamethasone,0.5mg/kg) by random number table method.There were 15 mice in each group.In addition to the normal group,all the other groups successfully produced the asthmatic airway inflammation model in mice,and the corresponding treatment measures were given.Comparison of mice after the last challenge 24h in bronchoalveolar layage fluid (BALF) of various inflammatory cytokines and serum immunoglobulin E (IgE),Hydroxyproline content in lung tissue and pathological changes were observed in lung tissue of rats with HE.Results The model control group BALF interleukin interleukin-4(IL-4),interleukin-5 (IL-5),interleukin-14 (IL-14),transforming growth factor-β 1 (TGF-β1),Vascular endothelial growth factor (VEGF),serum immunoglobulin E (IgE),hydroxyproline content in lung tissue were higher than the normal group (P ＜ 0.01).The levels of IL-4,IL-5,IL-14,TGF-β1,VEGF,IgE and Hydroxyproline content in lung tissue in the low dose group,the high dose group and the positive control group were lower than that in the model control group (P ＜ 0.01) in BALF.The levels of IL-4,IL-5,IL-14,TGF-β1,VEGF,IgE and hydroxyproline content in lung tissue in the high dose group of BALF were lower than those in the low dose group (P ＜ 0.05).Conclusion The water extract of red ginseng can achieve the therapeutic effect by reducing the airway inflammatory reaction of the asthmatic mice model.