Clinical observation on Danshen Chuangxiongqin Injection in treatment of posterior circulation ischemia vertigo / 药物评价研究

ABSTRACT

Objective To observe the clinical effect of Danshen Chuangxiongqin Injection in treatment of posterior circulation ischemia vertigo.Methods Patients (80 cases) with posterior circulation ischemia vertigo attack in Anhui Hospital of Traditional Chinese from March 2015 to March 2017 were randomly divided into control and treatment groups,and each group had 40 cases.Patients in control group were treated by Betahistine mesylate,6 mg/time (3 times/d) for 2 weeks.Patients in treatment group were iv administered with Danshen Chuangxiongqin Injection (10 mL/d) added into normal saline 250 mL,once daily for 2 weeks.After treatment,the efficacy was evaluated,and the levels of blood viscosity index,fibrinogen in two groups before and after treatment were compared.Results Total effective rate of observation group was 92.5％ which was higher than the control group's 72.5％ with significant difference (P ＜ 0.05).After treatment,the laboratory indexes (levels of blood viscosity,fibrinogen,and so on) were decreased,the improvement degree of these indexes in treatment group were significantly better than those in control group,with significant difference between two groups (P ＜ 0.05).Conclusion Danshen Chuangxiongqin Injection has significant effect in treating posterior circulation ischemia vertigo and it is worthy of clinical application and promotion.