Therapeutic efficacy of small dosage of methylprednisolone in treatment of sepsis and effect on immune cells / 药物评价研究

ABSTRACT

Objective To investigate the effect of small dosage of methylprednisolone in treatment of sepsis and the influence on immtme cells.Methods Totally 72 patients diagnosed with sepsis in Liqun Hospital from October 2014 to October 2016 were selected in this research.They were randomly divided into two groups36 patients in control group received conventional anti-infective treatment,and 36 patients in observation group were treated with small dosage of methylprednisolone on the basis of control group.The efficacy and level of immune cells were compared in two groups.Results The survival rate in observation group was significantly higher than that of control group (P ＜ 0.05).The difference of the incidence of complications and the level of immune cells before treatment between two groups had not statistical significance.CD4+ T lymphocytes and CD8+ T lymphocytes in observation group were significantly higher than those of control group after treatment,whereas the ratio ofCD4+/CD8+ and levels of CRP,TNF-α,PCT and IL-1 were lower than those of control group (P ＜ 0.05).Conclusion There is a significant effect of small dosage of methylprednisolone in treatment of sepsis,which can regulate apoptosis of T lymphocyte and inflammatory factor,reduce the immune response,improve the survival rate,and recommend the clinical popularization and application.