Vital role of transporters in renal drug elimination / 药物评价研究
Drug Evaluation Research
;
(6): 1216-1222, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-664700
ABSTRACT
Transporters are a class of functional membrane proteins which are broadly expressed in the kidney and play a vital role in the reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney.The renal proximal tubule is the primary site of transporter-mediated active transport for many drugs,including organic anion drugs,organic cation drugs and peptide drugs.Transporter-mediated drug-drug interactions may occur in the kidney when some drugs are co-administration.In this review,we focus on the location and function of major transporters in the kidney and summarize their vital role in renal drug elimination.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Drug Evaluation Research
Year:
2017
Type:
Article
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