Characteristics and prognosis of estrogen receptor negative breast cancer / 国际外科学杂志

ABSTRACT

Objective To explore the clinical and pathological characterizations of single progesterone receptor positive breast cancer,and identify the prognostic factors.Methods Obtained from SEER database,the author selected female patients diagnosed with invasive ductal breast cancer between January 1,2010,and December 31,2013.Seven hundred and seventy-five cases were single progesterone receptor positive breast cancer and 12 075 cases were triple negative breast cancers.Patient characteristics were compared using a Chi-square test or Fisher's exact test as appropriate.The Kaplan-Meier method was used to construct survival curves.The multivariate COX regression models were built to assess the independent association of all the variables.Results There was no significant difference between the two groups in terms of race (P =0.711),tumor location (P =0.325),marital status (P =0.255),Grade (P =0.773),tumor size (P =0.949),lymph node status (P =0.821),stage (P =0.567) or radiation treatment (P =0.434).Compared with triple negative breast cancer,patients with single progesterone receptor positive breast cancer tended to be younger(P =0.001),however no significant difference was found in breast cancer-specific survival(P =0.481)between the two groups.Larger tumor size [HR =2.777 (95％ CI1.295-5.955),P =0.009],and lymph node invasion [HR =3.669 (95％ CI1.881-7.154),P ＜ 0.001] could significantly increase the risk of dying from cancer in single progesterone receptor positive breast cancer patients.Conclusions Single progesterone receptor positive breast cancer presented with an early onset of disease,and experienced similar cancer-specific survival as triple negative breast cancer.Tumor size and lymph node status were independent prognostic factors.