Comparison on the efficacy of atorvastatin, simvastatin and rosuvastatin in the treatment of hypercholesterolemia / 药物评价研究

ABSTRACT

Objective To compare the efficacy of atorvastatin,simvastatin and rosuvastatin in the treatment of hypercholesterolemia.Methods Selected 120 cases of patients with hypercholesterolemia who were treated in our hospital from January 2014 to December 2016,divided into atorvastatin group,simvastatin group and rosuvastatin group.The blood lipid levels and the incidence of adverse reactions were compared between the three groups before treatment,after treatment for fourth weeks and after treatment for eighth weeks.Results The serum lipid level were significantly improved in three groups after treatment (P ＜ 0.05),and rosuvastatin group was significantly better than atorvastatin group and simvastatin group (P ＜ 0.05);the incidence of adverse reactions of the three groups showed no significant difference.Conclusion Atorvastatin,simvastatin and rosuvastatin can effectively improve the blood lipid levels in patients with hypercholesterolemia,and the effect ofrosuvastatin is the best.