Clinical efficacy of Ginkgo Leaf Extract and Dipyridamole Injection and Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in treatment of acute myocardial infarction / 药物评价研究

ABSTRACT

Objective To discuss the efficacy of Ginkgo Leaf Extract and Dipyridamole Injection and Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in treatment of acute myocardial infarction.Methods 60 cases of acute myocardial infarction were randomly divided into two groups.They were treated with routine treatment.The observation group (30 cases) was treated with Ginkgo Leaf Extract and Dipyridamole Injection on the basis of routine treatment.The control group (30 cases) was treated with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of routine treatment.The efficacy of Ginkgo Leaf Extract and Dipyridamole Injection and Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in treatment of acute myocardial infarction was evaluated by the efficacy,hemorheology before and after treatment,adverse reaction during treatment.Results The effective rate of observation group was 86.7％.The effective rate of control group was 90.0％.There was no statistical significance on effective rate between two groups.Before treatment,there were no statistical significance on blood viscosity,hematocrit,platelet aggregation rate between two groups.After treatment,the blood viscosity,hematocrit,platelet aggregation rate were decreased in two groups (P ＜ 0.05).The observation group ofhematocrit and platelet aggregation rate was lower than the control group (P ＜ 0.05).But the blood viscosity of two groups had no significant difference.According to the cost and the efficiency of single drug treatment,calculate the cost/effect ratio,the Ginkgo Leaf Extract and Dipyridamole Injection of cost/effect ratio was significantly less than that of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection (P ＜ 0.05).During treatment,there was no statistical significance on adverse reaction rate between two groups.Conclusion Ginkgo Leaf Extract and Dipyridamole Injection and Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection had a therapeutic effect on acute myocardial infarction with high safety.The Ginkgo Leaf Extract and Dipyridamole Injection could inhibit the platelet aggregation,reduce the hematocrit with low cost/effect value.