Efficacy and safety of Shexiang Baoxin Pill combined with isosorbidedinitrate in the treatment of unstable angina pectoris / 药物评价研究

ABSTRACT

Objective To explore the efficacy and safety of Shexiang Baoxin Pill combined with isosorbidedinitrate in the treatment of unstable angina pectoris.Methods 80 cases of UAP patients from Jun.2014 to Jun.2016 were given basic treatment plan,and 40 cases were randomly selected and treated with isosorbidedinitrate as the control group,and the other 40 cases were treated with Shexiang Baoxin Pill combined with isosorbidedinitrate.The incidence of angina pectoris and nitroglycerin dosage,angina pectoris curative effect,electrocardiogram (ECG) curative effect and adverse drug reactions were compared between the two groups.Results Before treatment,daily anginal attacks and nitroglycerin dosage of two groups had no significant difference;after treatment,daily anginal attacks and nitroglycerin dosage between two groups were obviously decreased,the differences of same group before and after treatment was statistically significant (P ＜ 0.05);and the treatment group was significantly less than the control group (P ＜ 0.05).The total effective rate of angina pectoris in the treatment group was higher than that in the control group,the difference was statistically significant (P ＜ 0.05).The total effective rate of ECG in the treatment group was higher than that in the control group,the difference was statistically significant (P ＜ 0.05).Conclusions Shexiang Baoxin Pill combined with isosorbidedinitrate in the treatment of UAP can significantly improve the efficacy,and it's adverse reaction is less.