Study on the difference of expressions of microRNAs in endometrial carcinoma combined with the metabolic syndrome / 国际检验医学杂志

ABSTRACT

Objective To study miRNA expression patterns in endometrial carcinoma(EC)combined with the Metabolic Syn-drome(MS)and non-combined with MS in order to explore the role of the microRNAs in EC combined with the MS.Methods Three fresh-frozen samples of endometrial carcinoma Combined with MS and 3 cases of non-Combined with MS and 1 case of nor - mal endometrium were collected.Total RNA was extracted from samples and miRNA microarray was used to evaluate the differenceof expression spectrum of miRNA.Results There were different expression of miRNA among the two groups of endometrium andnormal endometrium.There were 51 miRNA different expressions between EC combined with the MS and the normal endometri - um,and among them there are 15 upregulated miRNA and 36 downregulated miRNA.There were 9 miRNA different expressionsbetween EC non-combined with the MS and the normal endometrium ,and there are 3 upregulated miRNA and 6 downregulatedmiRNA among them.10 different miRNA were revealed between the two type of EC,and there are 4 upregulated miRNA and 6downregulated miRNA among them.Conclusion Different expressions of miRNA between EC Combined and non-Combined withMS may provide insights into their roles in the progression of EC .The study of miRNA contributes to elucidate the molecular mech - anismof endometrial carcinoma.