The study of the value of combined detection of serum tumor markers in the diagnosis of lung cancer / 国际检验医学杂志

ABSTRACT

Objective To explore the value of combined detection of serum tumor markers in the diagnosis of lung cancer.Meth-ods Electrochemiluminescence immunoassay was used to detect 5 kinds of tumor markers in 86 patients with lung cancer,92 pa-tients with benign lung disease and healthy persons,serum levels of neuron specific enolase(NSE),carcinoembryonic antigen (CEA),squamous cell carcinoma antigen(SCCAg),carbohydrate antigen 125(CA125)and cytokeratin fragment 21-1(CYFRA21-1).The difference of tumor markers in different patients and different pathological types of lung cancer and the difference of single and combined detection of tumor markers in the diagnosis of lung cancer were compared.Results The serum levels of NSE,CEA, SCC,CA125 and CYFRA211 in patients with lung cancer were significantly higher than those in benign lung disease group and healthy control group,and the difference was statistically significant(P<0.05).The average level of NSE in the serum of patients with small cell lung cancer was higher,CEA,CA125 levels in the serum of patients with adenocarcinoma was higher,and the levels of SCC and CYFRA211 in the sera of patients with squamous cell carcinoma were higher.The combined detection of serum tumor markers is more sensitive than that of the single detection,and the combined detection of NCE,CEA and CYFRA211 has relatively high specificity and accuracy.The combined detection of 5 serum indexes has the highest sensitivity,but its specificity is low,only 81.53%.Conclusion The single tumor marker has certain limitation whose sensitivity and specificity have great differences for dif-ferential diagnosis of different pathological types of lung cancer,and combined detection of the serum tumor markers can be mutual-ly complementary,which could have high sensitivity and accuracy.