Clinical application of FibroTouch in chronic liver disease and its comparison with multiparameter model / 重庆医学

ABSTRACT

Objective To evaluate the clinical application value of instantaneous elastic ultrasonic imaging (FibroTouch) and multiparameter model in the liver fibrosis diagnosis of the patients with chronic liver disease ,and to determine the best diagnostic cutoff point value of liver fibrosis stage diagnosed by FibroTouch .Methods Forty-eight cases of chronic liver disease conducted the liver tissue biopsy .The serological indexes of blood routine and liver function were collected .At the same time the liver stiffness measurement (LSM) was performed by using FibroTouch .The correlation between LSM and liver fibrosis was analyzed .The diag-nostic efficiencies were compared between cutoff value with APRI ,FIB-4 and FibroIndex multiparameter model .Results The liver puncture pathological results served as the gold standard .The Spearman rank correlation analysis showed that LSM ,APRI ,FIB-4 and FibroIndex multiparameter model were correlated with liver fibrosis (P<0 .05) .In the receiver operating characteristic (ROC) curve analysis ,the cutoff values of stage F1~F4 were in turn 6 .6 ,7 .7 ,10 .5 and 15 kpa respectively .The diagnostic value for diag-nosing whether having obvious fibrosis and liver cirrhosis was superior to APRI ,FIB-4 and FibroIndex multiparameter model .Con-clusion FibroTouch has a higher clinical application value in assessing liver fibrosis degree in the patients with chronic liver disease .