Effect of milk cytomegalovirus on clinical outcomes in infants with birth weight <1500 g / 临床儿科杂志

ABSTRACT

Objective To evaluate the safety of cytomegalovirus (CMV) DNA positive fresh breast milk in low birth weight infants (< 1500 g). Methods The low birth weight infants (< 1500 g) admitted to hospital were enrolled from May 1, 2015 to Dec. 31, 2015 and from May 1, 2016 to Dec. 31, 2016. All the subjects were breast fed by own mother's milk during the period of hospitalization, and was supplemented with the donated breast milk when the mothers' breast milk was insufficient. The CMV DNA content in mother's milk was measured by quantitative polymerase chain reaction (FQ-PCR) at two weeks after birth. If the CMV DNA in mother's milk was positive, during the period of May 1, 2015 to Dec 31, 2015, the milk was pasteurized before fed;during the period of May 1, 2016 to Dec. 31, 2016, the milk was fed without treatment. The differences of infections, liver injury, and hearing impairment among the untreated CMV DNA positive milk group, the pasteurized CMV DNA positive milk group, the untreated CMV DNA negative milk group were compared. Results A total of 222 low birth weight infants (<1500 g) were included, among whom 21 infants had birth weight < 1000 g. The CMV DNA was detected positive in 132 (59.46%) mother's milk. Sixty-seven infants were in the untreated CMV DNA positive milk group, 65 infants in the pasteurized CMV DNA positive milk group, and 90 infants in untreated CMV DNA negative group milk group. There were no significantly differences in gestational age, birth weight and sex among three groups. There were also no significant differences in the incidence of neonatal pneumonia, late sepsis, intestinal infection, liver damage, and hearing loss among three groups (P>0.05). Conclusions Feeding CMV DNA positive mother's breast milk does not adversely affect the clinical outcomes in low birth weight infants during hospitalization.