Influence of liver damage on serumβ2 micro-globulin for diagnosing renal function damage / 国际检验医学杂志

ABSTRACT

Objective To study the effect of serum β2 micro-globulin(β2-MG) level change on the diagnostic efficiency of renal damage .Methods A total of 254 cases of hepatorenal diseases in our hospital from October 2015 to October 2016 were selected and divided into the liver damage group(87 cases) ,renal damage group(113 cases) and hepatorenal damage group(54 cases) according to the hepatorenal function .Contemporaneous 85 cases undergoing healthy physical examination were collected as the control group .The levels of ALT ,AST ,β2-MG and creatinine(Cr) were detected in each group .Results There was no correlation between the serum ALT level and serum β2-MG level in liver damage group(r=0 .046 ,P=0 .674) ,while the serum AST level was correla-ted with the serum β2-MG level(r=0 .251 ,P=0 .020) ,the ASL/ALT ratio was correlated with the serum β2-MG level(r=0 .633 , P=0 .000);the serum β2-MG level in the liver damage group was significantly higher than that in the control group (Z= -9 .418 , P=0 .000) ,the Cr/β2-MG ratio was lower than that in the control group (Z= -2 .779 ,P=0 .005) ,and the Cr/β2-MG ratio in the hepatorenal damage group was lower that in the renal damage group (Z= -1 .487 ,P=0 .137) .The receiver operating characteristic curve analysis showed that the area under curve(AUC) ,cutoff value ,standard error ,95% confidence interval(CI) ,specificity and sensitivity of β2-MG were 0 .970 ,2 .61 μg/L ,0 .012 ,0 .946 -0 .994 ,0 .988 and 0 .852 in the renal damage group and 0 .832 ,4 .26μg/L ,0 .04 ,0 .755-0 .910 ,0 .862 and 0 .741 in the hepatorenal damage group respectively .Conclusion Hepatorenal damage mainly affects the diagnosis of serum β2-MG on mild renal damage .