Change of plasma lipopolysaccharide in Kazakh children with overweight and obesity and its relationship with physical measurement indexes / 重庆医学

ABSTRACT

Objective To understand the change of plasma lipopolysaccharide(LPS) in Kazakh children with overweight and obesity and to investigate the correlation between LPS and physical measurement indexes .Methods One hundred and four children were selected from 7648 native school age children in Altay area participating in the Epidemiological Investigation of Overweight and Obesity of School Age Children in Xinjiang as the research subjects .The physical measurement indexes such as body weight , height ,waist circumference(WC) ,hip circumference(HP) and blood pressure were measured ,and the body mass index (BMI) and waist to height ratio(WHtR) were calculated .LPS and biochemical indexes such as blood glucose(FPG) and blood lipid were detec-ted .Results With BMI increase ,the indexes including WC ,HP ,systolic blood pressure(SBP) and WHtR were also increased .The serum LPS and TG levels in the obesity group were significantly higher than those in the overweight group and control group .LPS had positive correlation with BMI grade (normal ,overweight and obesity ) ,r=0 .865 ,P= 0 .000 ,and also had positive correlation with WC (r=0 .556 ,P=0 .000) and WHtR(r=0 .477 ,P=0 .000) respectively ;the Kazakh school age chidren with WHtR abnor-mal increase had higher blood pressure and LPS level .WHtR and SBP had a positive correlation(r=0 .441 ,P=0 .000) .Conclusion LPS is correlated with overweight and obesity in Kazakh school age children .The child with abdominal obesity is easier to appear SBP abnormal elevation and LPS level increase .