Differences of erythrocyte distribution width and prothrombin time in patients with different degrees of liver injury / 重庆医学

ABSTRACT

Objective To investigate the change trend of erythrocyte distribution width (RDW) and prothrombin time (PT) in patients with different degrees of hepatic injury and its clinical significance .Methods A total of 100 inpatients with hepatitis B (HB group) ,100 patients with liver cirrhosis (cirrhosis group) and 50 patients with primary hepatocellular carcinoma (HCC) asso-ciated with HBV (liver cancer group) in the Second Affiliated Hospital of Chongqing Medical University from January 2014 to June 2015 were selected .The peripheral blood RDW and the average volume of erythrocytes (MCV) of all the subjects were detected by Sysmex XE-2100 automatic hematology analyzer .The PT was measured by Stago Rack Evolutio automatic coagulation analyzer and compared .Results There was no significant difference in RDW between the cirrhosis group and the HCC group (P=0 .099) ,and the difference between the other groups was statistically significant (P<0 .01) .As the disease progressed ,the RDW gradually in-creased .There was no significant difference in MCV comparison among all groups (P>0 .05) .There was no significant difference in PT between the HB group and the cirrhosis group (P=0 .234) ,and the difference between the other groups was statistically signif-icant (P<0 .01) .As the disease progressed ,PT gradually increased .Conclusion The increase of RDW and PT are related to the severity of liver injury .RDW may be an index to predict the degree of liver injury in patients .