Influence of hyperuricemia on ischemic stroke / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of hyperuricemia on ischemic stroke.Methods:A total of 175 Wistar rats were divided into blank control group(n=35,did not received any treatment)and middle cerebral artery occlusion (MCAO)group(n=140).According to given allopurinol(All)or not and its dose,MCAO group was further divid-ed into MCAO control group(n=35),MCAO+All(10mg)group(n=35),MCAO+ All(20mg)group(n=35) and MCAO+All(30mg)group(n=35).Serum and brain tissue levels and protein expressions of uric acid(UA), IL-6 and TNF-α,and cerebral infraction size were measured and compared among all groups.Results:Serum UA level of MCAO group was significantly higher than that of blank control group[(90.38 ± 31.27)mmol/L vs. (56.26 ± 8.82)mmol/L],P=0.001. Compared with MCAO control group,there were significant reductions in se-rum and brain tissue levels and protein expressions of IL-6[Serum(25.63 ± 0.7)ng/L vs.(23.52 ± 0.6)ng/L, (18.33 ± 0.9)ng/L,(20.11 ± 0.8)ng/L,brain tissue(1.20 ± 0.32)ng/L vs.(0.98 ± 0.26)ng/L,(0.64 ± 0.34) ng/L,(0.87 ± 0.16)ng/L]and TNF-α[Serum(200.42 ± 8.2)ng/L vs.(184.37 ± 6.2)ng/L,(165.75 ± 6.8)ng/L,(171.25 ± 7.5)ng/L,brain tissue(2.41 ± 0.6)ng/L vs.(2.12 ± 0.2)ng/L,(1.62 ± 0.8)ng/L,(1.77 ± 0.5) ng/L],and cerebral infarction size[(48.42 ± 6.2)% vs.(40.25 ± 3.1)%,(10.48 ± 4.2)%,(22.42 ± 5.2)%]in MCAO+All 10mg,20mg and 30mg group,P<0.05 or <0.01. Serum and brain tissue levels and protein expres-sions of IL-6 and TNF-α were the lowest,cerebral infarction size was the smallest in MCAO+ All(20mg)group. Conclusion:UA level significantly rises in rats with ischemic stroke,and reducing UA level can improve inflamma-tion and decrease infarction size,which may take effect via inflammatory molecule pathway.