Hirshfeld Surface and Structure Analysis of Two Co-crystal of Isonicotinic Acid Hydrazide / 医药导报
Herald of Medicine
;
(12): 12-15, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-665263
ABSTRACT
Objective Two co-crystals of isonicotinic acid hydrazide(INH)-malonic acid and INH-glutaric acid were prepared.The formation mechanism and intermolecular interaction were studied. Methods Three-dimensional structure of 2 co-crystals were obtained though single crystal X-ray diffraction(SXRD), and intermolecular interaction was analyzed using Hirshfeld surface method. Results INH-malonic acid crystalized in stoichiometric ratio of 10.5,while INH-glutaric acid in 11.Two co-crystals maintain their stable arrangement in space by hydrogen bond and van der Waals force. Conclusion With the existence of pyridine ring and carbohydrazide group in INH,which mainter-molecular interaction in co-crystal can be directly and clearly revealed by Hirshfeld surface analysis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Herald of Medicine
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS