Clinical and pathological characteristics of endometrial carcinoma in premenopausal and postmenopausal patients / 上海交通大学学报（医学版）

ABSTRACT

Objective·To analyze the clinical and pathological characteristics of endometrial carcinoma patients before and after menopause. Methods·Fifty-two premenopausal cases and 150 postmenopausal cases with endometrial carcinoma from December 2013 to March 2017 in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine were retrospectively analyzed. Results·The ratio of patients with hypertension in premenopausal group was 28.8％, which was significantly lower than that in postmenopausal group (P<0.01). In premenopausal group, the proportion of G3 in histological grading was 8.3％, and the ratio of deep myometrial invasion was 13.5％, all of which were significantly lower than those of postmenopausal group (P<0.05). The ratio of ovarian involvement was as high as 17.6％, which was significantly higher than that of postmenopausal group (P<0.05). There were no significant differences between the two groups in other clinical-pathological parameters such as obesity, diabetes, CA125, CA199, surgical-pathological staging, pathological type, vascular involvement, and lymph node metastasis. Conclusion·Premenopausal endometrial carcinoma is less malignant, while the probability of ovarian involvement is higher.