The Severity of Extent of Coronary Atherosclerosis Related to Plasma Homocysteine
Korean Circulation Journal
;
: 31-38, 2000.
Article
in Korean
| WPRIM
| ID: wpr-66535
ABSTRACT
BACKGROUND AND PURPOSE:
Hyperhomocysteinemia is supposed to be a risk factor for vascular occlusive disease. We want to evaluate the relationship between plasma homocysteine and the severity of coronary artery disease (CAD).METHODS:
In 121 consecutive patients (men62% age60+/-10 years) undergoing coronary angiography, plasma homocysteine, vitamin B(12), vitamin B(6) and folate levels were measured and angiographic findings were evaluated for the number of diseased vessels (diameter stenosis 50%), severity of stenosis of CAD and extent of CAD. Extent of CAD was defined as an index derived by assigning a score of 0-3 per segment depending on the proportion of lumen length irregularity and dividing the sum by the number of visualized segments.RESULTS:
Twenty-two patients had normal coronary artery 35 patients, minimal CAD (diameter stenosis < 50%) 30 patients, 1 vessel disease (VD) 22 patients, 2VD and 12 patients, 3VD. Homocysteine levels w+re not significantly different between the groups (normal7.6+/-4.2 mmol/L minimal CAD8.4+/-3.1mmol/L 1VD 8.0+/-4.8mmol/L 2VDs 10.2+/-6.0 mmol/L 3VDs 9.2+/-5.3 mmol/L). There was no relation between the stenosis scores of CAD and homocysteine levels (r=0.1). The extent scores of CAD were weakly correlated to the plasma homocysteine levels (r=0.22, p<0.05) and low density lipoprotein (LDL) cholesterol levels (r=0.28, p<0.01), and reversely correlated to high density lipoprotein (HDL) cholesterol levels (r=-0.31, p<0.01). The plasma homocysteine levels were reversely correlated to vitamin B12 (r=-0.27, p<0.01) and folate (r=-0.23, p<0.05) levels. In conclusion, the plasma homocysteine level was weakly but significantly correlated with the extent of CAD, not with the severity of stenosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Vitamin B 12
/
Vitamins
/
Coronary Artery Disease
/
Cholesterol
/
Risk Factors
/
Coronary Angiography
/
Constriction, Pathologic
/
Coronary Vessels
/
Hyperhomocysteinemia
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2000
Type:
Article
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