Dexamethasone in the prophylaxis of radiation-induced pain deterioration after pallia-tive radiotherapy for bone metastases from lung cancer / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 1194-1198, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-665433
ABSTRACT
Objective:
To evaluate the efficacy and safety of dexamethasone in alleviating radiation-induced pain deterioration follow-ing palliative radiotherapy in patients with bone metastases from lung cancer.Methods:
A total of 103 patients with bone metastases from lung cancer were randomly assigned into the observation group (n=51) and the control group (n=52). Dexamethasone (5 mg, iv) or placebo (saline, 1 mL) was administered after radiation. The incidence of pain deterionation in the two groups was compared. Re-sultsOf the 51 cases in observation group, 13 (25%) had pain deterioration. While 20 patients (38%) experienced aggravated pain in the control group (P=0.03).Conclusion:
Dexamethasone alleviated pain deterioration in patients with bone metastases from lung can-cer following palliative radiotherapy, which needs to be confirmed by further studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2017
Type:
Article
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