Advance of mechanism of ketogenic diet in refractory childhood epilepsy / 中华实用儿科临床杂志

ABSTRACT

Ketogenic diet(KD)has an auxiliary treatment for refractory epilepsy. It is recently demonstrated by clinical practice and researches that KD is effective in some children with refractory epilepsy. Despite much progress has been made on the anticonvulsant mechanisms of KD,no biological target related to clinical efficacy has been found so far. The biochemical characteristics of KD and its metabolic changes are discussed(including the roles of neuronal γ -aminobutyric acid,glutamate,ATP sensitive potassium channels and purine metabolism,and so on). The mechanism and recent progress of KD in the treatment of refractory childhood epilepsy are reviewed.