Static absorption compound anesthesia with intravenous anesthesia alone stress reaction and cellular immune function with gastric cancer surgery / 中国现代普通外科进展

ABSTRACT

Objective:To explore the analysis of the static absorption compound anesthesia with intravenous anesthesia alone stress reaction and cellular immune function in patients with gastric cancer surgery.Methods:From March 2014 to March 2014 were lines of gastric cancer patients,78 cases of elective surgical procedureS,using the random number table method was divided into control group and experimental group,each group of 39 cases,control group given simple intravenous anesthesia,patients given static absorption compound anesthesia,compared two groups of patients with preoperative 30 min (T0),cut the skin (T1),bi (T2),tube drawing immediate (T3),24 h after surgery (T4) different time points,such as serum C-reactive protein (CRP) and interleukin 2 (IL-2),the level of interleukin 8 (IL-8),CD4,CD8,the number of NK cells,and CD4/CD8 ratio.Re· sultsT2 IL-2,IL-8 point test group dropped to the lowest level,CRP rose to the highest,to T4 point back to the level before anesthesia,IL-2 and the control group,while the level of IL-8 T3 point minimum,CRP rose to the highest,and T4 point is still not fully recovered to the level before anesthesia,CRP T1 and T4 each point test group,IL-2 and IL-8 cytokine levels were significantly better than the control group,with significant difference (P＜0.05).T1 point,two groups of patients with CD4,NK cells and CD4/CD8 ratios were significantly decreased,CD8 levels increased significantly,CD4 T3 point test group began to rebound,NK cells and CD4/CD8 ratio,level of CD8 began to decline,and T4 point before anesthesia recovery level,and T4 point control indicators are still relatively preoperative levels have obvious deviation,T1 and T4 each point group CD4,NK cells and CD4/CD8 ratio than the control group obviously on the higher side,had clear statistical significance(P＜0.05),and each point CD8 levels have no obvious difference between groups(P＞0.05).ConelusionsDifferent anesthetic methods on gastric cancer surgery the patient's level of stress reaction and cell immune function all can produce certain effect,compared with the conventional simple intravenous anesthesia,the static absorption compound anesthesia can obviously relieve open perioperative stress response in patients with gastric cancer,reduce the inhibition of cellular immune level,is a kind of can effectively guarantee the anesthesia effect and prognosis of patients with ideal anesthesia method.