Effect of Moslae Herba volatile oil on rat models with the spleen and the stomach stranded by dampness / 中成药

ABSTRACT

AIM To study the therapeutic effect of Moslae Herba volatile oil on rat models with the spleen and the stomach stranded by dampness,and to form the modern pharmacology basis in terms of Moslae Herba's power in transforming dampness and harmonizing the center.METHODS The rat models of dampness-trapped spleen and stomach were induced by improper diet,damp environment and forced swimming.The model rats,ten in each group,were then randomly divided into model group,groups of low-dose,medium-dose and high-dose volatile oils,Twain-80 group,and positive drug group.The medication impact on rat models intragastrically administered for fif-teen days were assessed from body weight,food intake,water intake,urine,stool weight,spleen and thymus organ coefficient and gastric emptying and small intestinal propulsion rate and intestinal moisture index and serum motilin of rats (MTL) and gastrin (GAS),Na+-K +-ATP enzyme,amylase (AMS),interleukin-6 (IL-6),immunoglobulin G (IgG),gastrointestinal aquaporin 2 (AQP2),and indexes of pathological tissue change.RESULTS Compared with the model group,rats in each medication group displayed overall improvement in body weight,food intake,water intake,urine volume,spleen and thymus organ coefficient,gastric emptying and small intestinal propulsion rate,wet stool weight and intestinal water content,serum Na +-K +-ATP,GAS,AMS enzyme activity,IgG content,IL-6,MTL,AQP2 content of digestive tract,and the differences were statistically significant.CONCLUSION Moslae Herba works through its gastrointestinal absorption,and the ability in regulating water metabolism and immunity,that is to improve functioning of the spleen and the stomach in resolving dampness and harmonizing the center.