Effects of trimetazidine, a myocardial metabolism agent, on regulating 5-hydroxytrytamine system of rats with myocardial infarction and/or depression / 中华内科杂志

ABSTRACT

Objective 5-Hydroxytrytamine (5-HT) system was reported to be associated with myocardial infarction (MI) and depression. The aim of the present study was to study the effect of trimetazidine on 5-HT in MI and/or depression rats.Methods Ninety rats were divided into three groupstrimetazidine, sertraline and saline groups (n=30 in each group), and pretreated with trimetazidine, sertarline, or saline, respectively, by gavage once a day for 4 weeks. Thereafter, each group was further divided into three subgroups MI subgroup, depression subgroup, and MI + depression subgroup. Serum 5-HT,platelet 5-HT,5-HT2A receptor(5-HT2AR),and serotonin transporter(SERT)were detected by enzyme linked immunosorbent assay. Results Similar to sertarline, comparing to saline, trimetazidine treatment increased serum 5-HT [(221±23) pg/ml vs. (176±11) pg/ml; (395±31) pg/ml vs. (195±5) pg/ml; (348±28) pg/ml vs.(183±10)pg/ml],platelet 5-HT[(305±22)pg/ml vs.(130±27)pg/ml;(252±18)pg/ml vs.(175±5) pg/ml;(241±26)pg/ml vs.(181±11)pg/ml],and platelet 5-HT2AR levels[(247±13)pg/ml vs.(197±12)pg/ml;(320±13)pg/ml vs.(193±18)pg/ml;(334±17)pg/ml vs.(206±15)pg/ml]),and lowered platelet SERT levels [(248±11)pg/ml vs.(323±36)pg/ml;(188±7)pg/ml vs.(278±20)pg/ml;(170±23)pg/ml vs.(282±22)pg/ml] in MI,depression and MI+depression subgroups,respectively(all P<0.05).When compared the effect of trimetazidine and sertarline treatment, serum 5-HT and platelet 5-HT2AR in MI group were significantly lower in trimetazidine than in sertraline group (P<0.05), while serum 5-HT and platelet 5-HT, 5-HT2AR in depression group rats were significantly higher in trimetazidine than in sertraline group (P<0.05).Interestingly,platelet 5-HT2AR in MI+depression rats was much higher in trimetazidine than in sertraline group(P<0.05).Conclusions Trimetazidine,a kind of myocardial metabolism agent,could play a role on the regulation of 5-HT,5-HT2AR,and SERT levels in rats with MI and/or depression.