Dose-response relationship of anhydrous alcohol for thoracic sympathetic block in treating primary palmar hyperhidrosis / 中华麻醉学杂志

ABSTRACT

Objective To determine the dose-response relationship of anhydrous alcohol for thorac-ic sympathetic block in treating primary palmar hyperhidrosis. Methods Two hundred patients with prima-ry palmar hyperhidrosis, aged 18-33 yr, grade of palmar sweating 3 or 4, scheduled for elective surgery under thoracic sympathetic block, were divided into 5 different mixture of anhydrous alcohol and iohexol (iohexol anhydrous alcohol=1 5)groups(n=40 each)using a random number table. Under CT guid-ance, thoracic intervertebral puncture was performed between T3and T4until the needle tip reached the spot around T4and above capitis costae. The mixture of anhydrous alcohol 10 ml(group R1), 15 ml(group R2), 20 ml(group R3), 25 ml(group R4)and 30 ml(group R5)and iohexol was injected into the thoracic sympathetic ganglia on both sides. Effective block was defined as the rise in the palm tempera-ture of both hands more than 3℃ and sweating completely disappeared at 10 min after thoracic sympathetic block was performed with anhydrous alcohol. The median effective dose(ED50), ED95and 95% confi-dence interval(CI)of anhydrous alcohol for thoracic sympathetic block in treating primary palmar hyper-hidrosis were calculated by probit analysis. Results The ED50(95% CI)of anhydrous alcohol for thorac-ic sympathetic block in treating primary palmar hyperhidrosis was 1882(1564-2201)ml, and the ED95 (95% CI)was 2806(2420-3812)ml. Conclusion The ED50and ED95of anhydrous alcohol for tho-racic sympathetic block in treating primary palmar hyperhidrosis are 1882 and 2806 ml, respectively.