Base excision repair and targeted therapy strategies / 国际肿瘤学杂志

ABSTRACT

Base excision repair (BER) is an important pathway for DNA oxidative damage repair,and mutations in this pathway cause gene instability and increase cancer risk.A large number of studies have shown that abnormal expression of key proteins in the BER pathway in a variety of tumors,such as DNA glycosylase,apurinic/apyrimidinic endonuclease 1,DNA polymerase and so on.Single nucleotide polymorphisms of these proteins affect the repair activity of tumor cells,and are expected to be important indicators for the diagnosis,treatment and evaluation of prognosis.