Changes of serum neuron specific enolase and S100-β protein and their correlations with cognitive impairment in patients with moderate traumatic brain injury / 中华创伤杂志

ABSTRACT

Objective To analyze the correlation of the levels of serum neuron specific enolase (NSE) and S100-β protein with cognitive impairment in patients with moderate traumatic brain injury (mTBI).Methods A retrospective case series study enrolled 87 patients with mTBI treated from January 2015 to October 2016.There were 50 males and 37 females,aged 14-60 years [(37.8-12.6)years].The Glasgow Coma Score (GCS) was 9-12 points,among which were 9-10 points in 36 cases and 11-12 points in 51.The cognitive function was assessed by the Montreal Cognitive Assessment Scale (MoCA).The patients with MoCA ＜ 26 points were assigned into cognitive impairment group (study group,54 cases),while the patients with MoCA ≥ 26 points was assigned into non-cognitive-impairment group (control group,33 cases).The levels of serum NSE and S100-β protein were compared,and the correlation of levels of serum NSE and S100-β protein with cognitive dysfunction (assessed by MoCA and GCS) was analyzed.Results The levels of serum NSE and S100-βprotein were (35.7 ± 11.0) ng/L and (1.8 ± 0.5) ng/L,respectively in study group,which were significant higher than that in control group [(22.6 ±9.4)ng/L and (1.2 ±0.5)ng/L,respectively] (P＜0.01).The levels of NSE [(33.7 ± 10.0)ng/L] and S100-β [(1.7 ± 0.4)ng/L] in patients with GCS 9-10 points were higher than those of NSE [(19.4 ± 9.0) ng/L] and S100-β [(1.3 ± 0.5) ng/L] in patients with GCS 11-12 points (P ＜ 0.01).The levels of serum NSE and S100-β protein in mTBI patients were negatively correlated with the MoCA score (r =-0.693,-0.721,P ＜ 0.05) and GCS (r =-0.527,-0.796,P ＜ 0.05).Conclusion The levels of serum NSE and S100-β protein are increased,and are correlated to the occurrence of cognitive impairment in patient with mTBI.