Effect of enteral immunonutriton on patients undergoing renal transplantation / 肠外与肠内营养

ABSTRACT

Objective:To evaluate the safety and effectiveness of early enteral immunonutrition on the patients undergoing renal transplantation.Methods:Forty-six patients undergoing renal transplantation were randomly divided into two groups,named enteral immunonutrition (EIN) group and regular enteral nutrition (EN) group (given EIN and EN respetively).The humoral immunity,cellular immunity,serum albumin,prealbumin,hemoglobin,cholesterin and the incidence of rejection were observed in order to compare the therapeutic efficacy of two kinds of nutrition therapy.Results:At the 1 st day,humoral immunity and cellular immunity were no significant differences between two groups.At the 7th day,the serum levels of IgM and IgA were significant higher in EIN group than those in EN group (P ＜ 0.05) except IgG (P ＞ 0.05).The serum level ofCD3+ was also significant higher in EIN group than in EN group at the 7th day after operation.The humoral immunity and cellular immunity were significant higher in EIN group than in EN group (P ＜ 0.05) at the 28th day after operation.The serum albumin,prealbumin,hemoglobin,cholesterin level had no significant differences between two groups before operation or at the 1 st,7th,28th day after operation (P ＞0.05),although they were higher on the 28th day than 1st day both in two groups (P ＜ 0.05).But cholesterin level had no significant differences between two groups at the 28th day and 1st day (P ＞ 0.05).The incidence of rejection was similar in two groups within 30 days after operation.Conclusion:The EIN can improve the humoral immunity and cellular immunity with a better effect than EN.The early postoperative EIN can improve the clinical outcomes of the patients undergoing renal transplantation.