The changes of laboratory indexes in children with hepatoblastoma between pre-treatment and post-treat-ment with pirarubicin chemotherapy / 国际儿科学杂志

ABSTRACT

Objective To investigate the laboratory indexes changes of cardiotoxicity before and after pirarubicin(THP)chemotherapy in children with hepatoblastoma(HB).Methods The clinical data of 76 cases were collected whose were postoperative HB children and were given THP chemotherapy from January 2012 to June 2015 in our hospital.Changes of serum laboratory indexes including N-terminal pro-brain natriuretic peptide (NT-proBNP)and creatine kinase isoenzymes(CKMB)were analyzed by statistical methods between pre-treat-ment and post-treatment with THP.Results There was no definite cardiotoxicity case in 76 children with HB. The serum NT-proBNP level of pre-treatment was(80.93 ± 74.13)ng/L and the level of post-treatment was (211.85 ± 211.42)ng/L.The changes of serum NT-proBNP showed statistical difference(P=0.00,P<0.05) between pre-treatment and post-treatment.The serum NT-proBNP level in group with THP cumulative doses more than 200 milligram per square meter was(225.67 ± 237.63)ng/L,which was higher than that level of NT-proBNP ((182.39 ± 140.43)ng/L)in group with THP cumulative dose less than or equal to 200 milligram per square meter.But the difference of the two groups showed no statistical significance(P=0.338,P>0.05).The pre-treatment level of CKMB was(23.08 ± 13.52)U/L and post-treatment level was(30.90 ± 13.92)U/L.The changes of serum CKMB level showed statistically difference(P=0.00,P<0.05).Conclusion The serum NT-proBNP level of postoperative HB was significantly increased after given THP chemotherapy,which might have a certain clinical significance for early monitoring of cardiotoxicity.