Clinical and imaging features of CADASIL / 国际脑血管病杂志

ABSTRACT

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease.Migraine,recurrent subcortical ischemia,progressive cognitive impairment,and emotional disorders are the main features.The diagnosis of CADASIL depends on typical clinical symptoms and neuroimaging findings,and it is confirmed by skin biopsyz and gene testing.In recent years,some new insights have been obtained in the clinical and imaging features of CADASIL This article reviews the research progress in this field.