Updates on airway epithelial cells in asthma / 国际儿科学杂志

ABSTRACT

Airway epithelial cells,which are the first line of defense against inhaled pathogens and parti-cles,play an important role in initiating airway inflammation,mucous metaplasia and keeping type 2 inflamma-tion in asthma.Mucous metaplasia of airway epithelial cells is one of the important part of airway reconstitution. The mucous overproduction in small airway leads to mucous plug,which is closely related to the high mortality of asthma.Multiple signaling and transcriptional networks influence goblet cell differentiation.These include JAK and the transcription factor STAT6,Notch,EGFR,et al.In this article,the changes of epithelial cells in asthma and its role at the beginning of asthma are described.Furthermore,the progress in airway mucous metaplasia and several related cell signaling pathways were focused on,which may provide some potential target to inhibit the secretion of mucous in asthma.