Role of cyclophilinD in induction of the regulated necrosis / 基础医学与临床
Basic & Clinical Medicine
;
(12): 1625-1628, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-666972
ABSTRACT
CyclophilinD ( CypD) , a member of cyclophilins family displays a variety of biological function .CypD lo-cates in the mitochondrial matrix .As an component of mitochondrial permeability transition pore ( mPTP ) , CypD plays an important role in the regulating of mPTP opening , which leads to mitochondrial dysfunction and CypD-de-pendent regulated necrosis .Elucidation of the mechanisms of CypD in regulating mPTP and the regulated necrosis will provide novel insights in injury-relevant diseases , such as cardiac or cerebral ischemia .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Basic & Clinical Medicine
Year:
2017
Type:
Article
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