Association between PD-1 genetic variants and the risk of epithelial ovarian cancer / 基础医学与临床

ABSTRACT

Objective To evaluate the effect of PD-1 gene polymorphisms on the risk of developing epithelial ovarian cancer ( EOC) and patients'outcomes.Methods A case-control study was performed in 620 EOC pa-tients and 620 control women.The genotype and allele frequencies of PD-1.1 A/G and PD-1.5 C/T polymor-phisms were determined using the polymerase chain reaction/ligase detection reaction ( PCR-LDR ) method. Results There were significant differences in the genotype and allele distribution frequencies of the PD-1.1 A/G between cases and controls(P=0.028 and P=0.02, respectively).Compared with the AA genotype , AG and GG genotypes may significantly decrease the risk of developing EOC ( OR=0.71, 95%CI=0.54-0.94; OR=0.68, 95%CI=0.50-0.94,respectively).There was no significant difference in the genotype distribution frequency of the PD-1.5 C/T between cases and controls ( P=0.096 ) , but the frequency of T alleles was significantly lower in the EOC cases than that in the controls ( P=0.033) .Compared to the carriers with C alleles , the carriers with T alleles were at a significantly decreased risk of developing EOC ( OR=0.82 , 95%CI=0.69-0.98 ) .Conclusions PD-1.1 A/G and PD-1.5 C/T polymorphisms are potential molecular markers for predicting the risk of epithelial ovarian cancer in Chinese norther women .