Protective mechanism of GLP-1 on kidney in diabetic kidney disease patients / 中国糖尿病杂志
Chinese Journal of Diabetes
;
(12): 957-960, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-667007
ABSTRACT
Diabetic kidney disease is a common complication in patients with diabetes mellitus and so far,lacking effective therapy aiming at it.Glucagon like peptide-1 (GLP-1) receptor agonist is a novel hypoglycemic agent associated with incretin.Studies have shown that GLP-1 have additional renal protection independent of its hypoglycemic effect,mainly through the mechanisms such as antihypertension,reducing glomerular hyperfiltration,lowering proteinuria,anti-inflammatory,antioxidative stress and anti-RASS.In this review,we will summary their renal effects and mechanisms from the basic and clinical evidences.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Diabetes
Year:
2017
Type:
Article
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