Progress in the application of mass spectrometry in reference measurement procedures / 中华检验医学杂志

ABSTRACT

The establishment of laboratory medicine reference system is an important way for routine detection results to achieve traceability.The complete reference system consists of reference measurement procedures,reference materials and reference laboratories.The reference measurement procedure is usually characterized by a thorough study with a small measurement uncertainty.Based on the advantages of high specificity and high sensitivity in quantitative analysis, mass spectrometry plays an important role in the research of the reference measurement procedures in laboratory medicine.In the past 40 years, mass spectrometry technology has been more and more widely applied in medicine, electrolytes, metabolites and substrates, non-electrolyte metals, non-peptide hormones, protein and vitamin.It provides a powerful guarantee for the precise detection of these well-defined measureds.