Effect of highly efficient antiretrovirus combined with anti-immune therapy on patients with AIDS complicating pulmonary tuberculosis / 国际检验医学杂志

ABSTRACT

Objective To study the influence of highly efficient antiretrovirus combined with anti-immune therapy on the im-mune function and metabolism in the patients with AIDS complicating pulmonary tuberculosis (TB) .Methods 170 patients with AIDS complicating pulmonary TB from May 2013 to May 2013 were selected and divided into the observation group and control group according to the random number table method ,85 cases in each group .The control group was given highly efficient antiretro-virus and conventional anti-TB medication therapy ,while on this basis the observation group was combined with anti-immune thera-py .Then the indicators of immune function ,lipid metabolism ,toxic and side reactions were compared between two groups .Results The CD4+ and CD4/CD8+ levels after 6-month treatment in the observation group were significantly higher than those in the con-trol group(P<0 .05) ,the CD8+ level was significantly lower than that in the control group(P<0 .01);Serum total cholesterol ,tria-cylglycerol and low density lipoprotein cholesterol levels in the observation group were significantly lower than those in the control group(P<0 .05) ,the high density lipoprotein cholesterol level was significantly higher than that in the control group (P<0 .01);the occurrence rate of toxic reactions and side effects such as nausea and vomiting in the observation group was 14 .12% ,which was significantly lower than 27 .06% in the control group(χ2 =4 .353 ,P<0 .05) .Conclusion Highly efficient antiretrovirus combined with anti-immune therapy is conducive to improve the immune function in the patients with AIDS complicating pulmonary TB ,de-creases its influence on the body metabolism ,and reduces the digestive tract reactions such as nausea and vomiting .