Therapeutic value of endoscopic ultrasound-guided celiac plexus neurolysis for pain associated with advanced pancreatic carcinoma in 29 patients / 中华消化内镜杂志

ABSTRACT

Objective To evaluate the clinical efficiency of endoscopic ultrasound-guided celiac plexus neurolysis(EUS-CPN)for pain associated with advanced pancreatic carcinoma.Methods EUS-CPN was performed in 29 patients with advanced pancreatic carcinoma in Hangzhou First People′s Hospital from May 2010 to April 2015. The pain status before and after treatment was measured by visual analogue scale (VAS),and the clinical efficacy was assessed by pain anesis rate(PAR). Results All the 29 patients successfully completed EUS-CPN. The mean VAS value of the first day after treatment(3.6±1.5)was lower than that of preoperative(8.2±2.3,P=0.00). The mean VAS value of 1 month after treatment(2.0±0.6) was statistically different compared with the value of the first day after treatment(P=0.00). There were 10, 9,4,and 3 patients who had complete,obvious,moderate and mild relief,respectively. Three patients had no pain relief. The overall efficiency rate was 79.3%(23/29). Conclusion EUS-CPN is a safe and effective method for relieving pain in pancreatic carcinoma.