Correlation between serum lipid specific serine protease inhibitors and inflammatory factors in patients with coronary heart disease / 国际检验医学杂志

ABSTRACT

Objective To observe the correlation between serum fatty specific serine protease inhibitor (vaspin) and inflammato-ry factors in the patients with coronary heart disease (CHD) .Methods 114 cases of CHD(CHD group) in our hospital from April 2010 to April 2015 were selected and divided into the stable angina group ,unstable angina group and acute myocardial infarction group according to the disease type ,and divided into the 1-vessel lesion group ,2-vessel lesion group and 3 or more vessel lesion group according to the coronary lesion vessels .At the same time 45 healthy persons were selected as the healthy control group .The enzyme-linked immunosorbent assay(ELISA) was adopted to detect the levels of vaspin ,tumor necrosis factor-α(TNF-α) ,interleu-kin (IL)-6 ,IL-10 and C reactive protein(CRP) .Results The vaspin level in the CHD group was significantly lower than that in the healthy control group ,while the levels of TNF-α,IL-6 ,IL-10 and CRP were significantly higher than those in the healthy control group ,the difference between the two groups was statistically significant (P<0 .05).The levels of vaspin in the stable angina pec-toris group ,unstable angina group and acute myocardial infarction group decreased in turn ,and the levels of vaspin in the 1-vessel lesion group ,2-vessel lesion group and 3 or more vessel lesion group decreased in turn ;the levels of CRP、IL-6、IL-10、TNF-αin the stable angina pectoris group ,unstable angina group and acute myocardial infarction group increased in turn ,and the levels of CRP、IL-6、IL-10、TNF-αin the 1-vessel lesion group ,2-vessel lesion group and 3 or more vessel lesion group increased in turn ;the differ-ence between the groups was statistically significant (P<0 .05) .The CHD severity was positively correlated with the levels of CRP , IL-6 ,IL-10 and TNF-α(P=0 .007 ,0 .003 ,0 .004 ,0 .005) ,and negatively correlated with the vaspin level (P=0 .002) .Conclusion The vaspin level is closely related to the inflammatory factors in CHD patients ,and is related with the vascular lesions severity of CHD .