Galactose base level of N-sugar chain and clinical significance in immunoglobulin of schizophrenia / 中华检验医学杂志

ABSTRACT

Objective To investigate the correlation among serum galactose immunoglobulin of quantitative change, total IgG and CIC(circulating immune complexes)levels in patients with schizophrenia.Methods Test the number changed of PVL affinity type Ig in 80 patients with schizophrenia and 80 controls′serum with the PVL affinity ELISA method.The specimens without central nervous system organic disease,heart,liver,kidney diseases, and autoimmune diseases are collected from March to June 2015 in Hospital 261 of PLA′s hospitalized patients.The total of cases is 80.The cases of male are 52,and the cases of female are 28.The age is from 19 to 60,and the average of age is(27.2 ±6.2).Control group is selected from health checkers from the same petiod.The cases of male are 52,and the cases of female are 28.The age is from 19 to 61,and the average of age is(27.8 ±5.4).The relationships among serum PVL-Ig,total IgG and CIC levels in patient group and control group were investigated by rectilinear correlation analysis.Results The serum PVL-IgG level(3.128 ±0.531)(A value)in schizophrenia was significantly higher than control group(2.672 ±0.492)(A value),(t=3.846,P<0.01).PVL-IgM(0.351 ±0.082)(A value)and PVL-IgA(1.287 ±0.205)(A value)compared with the control group(0.362 ±0.073,1.203 ± 0.216)(A value), there was no difference(t=0.241,0.6013;P>0.05).There was positive correlation between serum PVL-IgG and CIC in patients(r=0.423 1,P<0.01).There was no significant correlation with IgG,IgM and IgA.Conclusions People with schizophrenia have an excess of PVL-IgG expression,which maybe participated in the pathological process of immunological injury.PVL-IgG may be one of the molecular mechanisms of patients′CIC stranded or cleared of obstacles.