Clinical significance of joint detection of urine light chains ,urine microalbumin and urine α1-microglobulin in early diabetic kidney injury / 国际检验医学杂志

ABSTRACT

Objective To explore the clinical value of joint detection of urine light chains ,urine microalbumin and urine α1-mi-croglobulin in early diabetic kidney injury .Methods 218 cases type 2 diabetes mellitus(T2DM ) were selected as the observational group and 62 cases undergoing healthy physical examination as the control group .The rate scattering turbidimetry method was a-dopted to detect urinary κlight chains ,urinary λlight chains ,urinary micro-albumin(mALB) ,α1-microglobulin(α1-MG) in the two groups .Then the test results were performed the comparative analysis .Results The positive rate of urine κ light chains ,urine λlight chains ,mALB and α1-MG in the observational group were significantly higher than those in the control group ,the difference was statistically significant(P<0 .01);theκ/λvalue had no statistical difference between the observation group and control group (P>0 .05) .The receiver-operating characteristic curve analysis showed that the area under curve (AUC) of urineκlight chains ,u-rineλlight chains ,mALB and α1-MG ,and 95% CI were 0 .763 ,0 .541 ,0 .854 ,0 .807 and 0 .708 -0 .817 ,0 .464-0 .691 ,0 .811-0 .897 and 0 .758-0 .856 respectively ,AUC and 95% CI of joint detection of 4 urine indicators were 0 .919 and 0 .886-0 .951 ,the difference was statistically significant(P<0 .01) .Conclusion The combined detection of urine κ light chains ,urineλ light chains , mALB and α1-MG has an important clinical value for predicting early diabetic kidney injury .