Clinical Significance of Plasma D-Dimer Detection in Cervical Cancer, Uterine Cancer and Ovarian Cancer / 现代检验医学杂志

ABSTRACT

Objective To explore the clinical significance of detection of plasma D-dimer in patients with cervical cancer,uterine cancer and ovarian cancer.Methods Total 35 cervical cancer patients,32 uterine cancer patients and 30 ovarian cancer patients were collected from Yunxiao Traditional Chinese Medicine Hospital of Zhangzhou city and the First Hospital of Zhangzhou China Merchants Economic and Technological Development Zone from October 2013 to July 2015.The plasma D-dimer was detected and compared with cervicitis,hysteromyoma,ovarian cyst and healthy control respectively.Relativity between the level of plasma D-dimer with the International Federation of Gynecology and Obstetrics (FIGO) staging was anslyzed.The diagnostic value of plasma D-dimer in cervical cancer,uterine cancer and ovarian cancer was assessed by receiver operating characteristic (ROC)curves.Results The level of plasma D-dimer in the cervical cancer group was significantly higher than that in the cervicitis group,the uterine cancer group was higher than that in the uterine leiomyoma group,and the ovarian cancer group was higher than that in the ovarian cyst group too (t=5.91 ～ 7.17,all P＜0.01).It was no significantly differentia compare with cervical cancer group,uterine cancer group and ovarian cancer group (F=0.10,P＞0.05).Plasma D-dimer level in cervicitis group,hysteromyoma group and ovarian cyst group was no significantly differentia (F=2.47,P＞0.05) but it was significantly high in cervicitis than hysteromyoma at post test (P＜0.05).Compared with healthy control group,the plasma D-dimer level was significantly rise in cervical cancer,uterine cancer,uterine cancer,cervicitis and ovarian cyst (t=2.43～7.53,P＜0.01～0.05),while no significantly differentia in hysteromyoma (t=1.04,P＞0.05).It was significantly differentia and increases as the FIGO staging in cervical cancer,uterine cancer and uterine cancer (F=15.06 ～ 19.02,all P＜0.01,r=0.625 ～ 0.855,all P＜0.01).The area under the ROC curve (AUC) of the three tumors diagnosed by D-dimer was 0.964,0.980 and 0.983,with sensitivity of 82.9 ％,90.6 ％ and 86.7 ％ respectively,and specificity of all 100％,which was of high diagnostic value.Conclusion There are hyperactivity of thrombosis and fibrinolysis in cervical cancer,uterine cancer and ovarian cancer.The plasma D-dimer levels can be used as the reference index of diagnosis and staging.