Clinical Application of Detection of Plasma vWF:Ag and S100B in Ischemic Cerebral Apoplexy Disease / 现代检验医学杂志

ABSTRACT

Objective To explore the clinical application value of S100B and vWFAg levels in ischemic cerebral apoplexy disease.Methods The plasma and clinical data from 85 cases of patients with ischemic cerebral apoplexy were collected,extracted 38 cases of volunteer blood plasma from a random sample of the general population and quantitative detected S100B levels by ELISA method,using Sysmex CA-7000 automatic blood coagulation instrument to detect plasma vWFAg levels.The carotid artery diameter and intima-media thickness of all the participants were detected by GELOGIC9 color doppler ultrasonic diagnostic instrument.Results The levels of plasma vWFAg in the CS group,the NCS (％) group and the control group were 176.8±56.3,128.9±37.6 and 93.7±30.1,which of plasma S100B (μg/L) were 2.8±1.3,1.9±0.9 and 1.3 ±0.7.Stroke patients could be divided into CS group and NCS group,compared with control group,observed the changes and the relationship of ischemic stroke disease for plasma S100B and vWFAg levels.The levels of plasma vWFAg and called S100B in the two case groups were increased compared with those in controls,the differences had statistical significance (F=125.9,89.3,P＜0.01).In CS and NCS group,vWFAg and S100B were comparative differences and statistically significant (F=125.9,89.3,P＜0.01),the levels of the two markers in the CS group were higher than in replication group.In CS group,the plasma levels of vWFAg and S100B were positively correlated (r=0.836,P＜0.01).In CS group,plasma levels of vWFAg were associated with carotid artery diameter and intima-media thicknes (r=-0.853,0.923,P＜0.01 and r=-0.783,0.823,P＜0.01),which of S100B did so (r=-0.820,0.833,P＜0.01).Conclution Detection of the levels of vWFAg and S100B can predict the degree of danger of ischemic cerebral apoplexy disease and estimate the development of the disease.