Effects of Resveratrol on Streptozotocin-induced Diabetic Neuropathic Pain in Rats / 中国医科大学学报

ABSTRACT

Objective To investigate the effects of resveratrol on diabetic neuropathic pain induced by streptozotocin (STZ) in rats.Methods The subjects were pretreated with resveratrol (40 mg/kg) intraperitoneally,30 min before an intraperitoneal injection of STZ (60 mg/kg).Mechanical and cold allodynia were tested before and 1 to 4 weeks after the drug administration.Thermal hyperalgesia was also investigated.In addition,the transient receptor potential (TRP) Ankyrin 1 (TRPA1) and TRP melastatin 8 (TRPM8) expression levels in the dorsal root ganglia (DRG) were evaluated.Results Pretreatment with resveratrol significantly inhibited STZ-induced mechanical and cold allodynia,but not thermal hyperalgesia.The STZ injection increased TRPM8 expression levels (P ＜ 0.05),but not TRPA1 (P＞ 0.05) expression levels,in the DRG.Pretreatment with resveratrol decreased STZ-induced TRPM8 expression levels in the DRG (P ＜ 0.05).Conclusion The results demonstrated that pretreatment with resveratrol had strong anti-allodynic effects in STZ-induced diabetic tats,which might be associated with TRPM8 located in the DRG.