Correlation between anti-angiotensin type 1 receptor antibody and prognosis of sensitized renal transplant recipients / 中华器官移植杂志

ABSTRACT

Objective To evaluate the correlation between anti-angiotensin type 1 receptor (AT1R) antibody and the prognosis of HLA-positive sensitized renal transplant recipients.Methods Forty-three HLA-positive sensitized recipients positive for AT1R antibodies were tested.HLA antibodies were tested by Lurninex-based single antigen beads assay.AT1R antibody was detected by ELISA.The patients were divided into two groups according to AT1R antibody levelAT1R-AA positive group (AT1R-AA ≥9 U/mL,n =12) and AT1R-AA negative group (AT1R-AA＜9 U/mL,n =31).We also analyzed the rate of rejection and allograft loss,HLA antibodies level,kidney function,kidney survival and patients' survival,etc.Results The rate of allograft loss in the AT1RAA positive group and the AT1R-AA negative group was 41.7％ (5/12) and 9.6％ (3/31)respectively (P =0.02).The rate of AMR in the AT1R-AA positive group and the AT1R-AA negative group was 25％ (3/12) and 0.0％ (0/31) respectively (P =0.03).Meanwhile,the one-yearpatients' survival in the AT1R-AA positive group was lower than in the AT1R-AA negative group (P＜0.05).There was no significant association between AT1R-AA (mean AT1R-AA =8.7 U/mL)and MFI (mean MFI =9119).AT1R antibody was one of risk factors to acute antibody-mediated rejection and kidney allograft loss for sensitized recipients.Conclusion The rate of allograft loss in the AT1R-AA positive group and the AT1R-AA negative group was 41.7％ (5/12) and 9.6％ (3/31)respectively (P =0.02).The rate of AMR in the AT1R-AA positive group and the AT1R-AA negative group was 25％ (3/12) and 0.0％ (0/31) respectively (P =0.03).Meanwhile,the one-yearpatients' survival in the AT1R-AA positive group was lower than in the AT1R-AA negative group (P ＜0.05).There was no significant association between AT1R-AA (mean AT1R-AA =8.7 U/mL)and MFI (mean MFI =9119).AT1R antibody was one of risk factors to acute antibody-mediated rejection and kidney allograft loss for sensitized recipients.