Clinical value of the combination of procalcitonin and hypersensitive C-reactive protein detection for the assessment of bacterial pneumonia / 中国基层医药

ABSTRACT

Objective To explore the clinical value of the combination of procalcitonin (PCT) and hypersensitive C-reactive protein (hs-CRP) detection for the assessment of bacterial pneumonia.Methods Fifty bacterial pneumonia patients were randomly selected and included into the observation group,another fifty healthy subjects were selected as the control group in the same period.The levels of hs-CRP and PCT in the two groups were detected,and the detection results were comparatively analyzed.Results The PCT level [(3.13 ± 0.43) μg/L] and hs-CRP level[(55.37 ± 9.64)mg/L] in the observation group before treatment were significantly higher than those in the control group [PCT level (0.04 ± 0.01)μg/L,hs-CRP level (6.46 ± 0.89)mg/L],and the differences were statistically significant (t =50.7993,36.3980,all P ＜0.05).There were no significant differences in the PCT and hs -CRP levels between the two groups after treatment (t =0.5000,0.9444,all P ＞ 0.05).The PCT level (3.11 ±0.85) μg/L and hs-CRP level (20.31 ± 3.96) mg/L in the patients with CURB-65 score of 4-5 were significantly higher than those in patients with CURB-65 score of 0-1 and 2-3 [PCT level (1.19 ± 0.42) μg/L and hs-CRP level (1.86 ± 0.53) mg/L in patients with CURB-65 score of 0-1,PCT level (1.82 ± 0.54) μg/L and hs-CRP level (9.85 ± 1.21)mg/L in patients with CURB-65 score of 2-3],and the differences were statistically significant (t =8.3565,5.0788,20.8283,10.9947,all P ＜ 0.05).Conclusion The levels of serum PCT and hs-CRP are significantly increased in the patients with bacterial pneumonia,but the levels are decreased significantly after treatment.The combination of hs-CRP and PCT detection has significant value for the assessment of bacterial pneumonia,which is helpful to evaluate the condition of the disease,and has great clinical significance.