Analysis of Parental Decisions Based on Sex Chromosome Abnormalities Detected Prenatally: A Ten-year update (2001-2010)
Journal of Genetic Medicine
;
: 17-21, 2012.
Article
in English
| WPRIM
| ID: wpr-66746
ABSTRACT
PURPOSE:
The aim of this study was to analyze parental decisions regarding pregnancies in which the fetus had sex chromosome abnormalities (SCA) over a ten-year period. MATERIALS ANDMETHODS:
We collected and reviewed records from our hospital for 2001-2010 and a genetic specialist provided-genetic counseling.RESULTS:
We diagnosed 130 cases (0.71%) with SCA out of 18,376 prenatal cases from 2001 to 2010. We reviewed the records and the results of all pregnancies. We also included cases (n=84) of apparently normal anatomic fetuses to analyze the factors influencing parental decisions. We excluded 34 cases with an obvious anomaly or a presumably bad outcome and 12 cases that were not followed up. Forty-three couples (51.2%) continued their pregnancies while forty-one (48.8%) terminated them. Of 38 mosaicism cases, 21 (55.3%) were continued. Among the 20 pregnancies assisted by reproductive techniques, 15 (75%) were continued (P=0.02). More pregnancies were continued when genetic counseling was provided (61.9%) compared to cases in which it was not provided (19%) (P=0.01).CONCLUSION:
Genetic counseling is important in providing appropriate information to parents. Establishing guidelines and protocols will help both obstetricians and parents to make informed decisions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parents
/
Prenatal Diagnosis
/
Sex Chromosome Aberrations
/
Sex Chromosomes
/
Specialization
/
Family Characteristics
/
Reproductive Techniques
/
Fetus
/
Genetic Counseling
/
Mosaicism
Type of study:
Diagnostic study
/
Practice guideline
/
Prognostic study
Limits:
Humans
/
Pregnancy
Language:
English
Journal:
Journal of Genetic Medicine
Year:
2012
Type:
Article
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