Antibacterial enhancement of antibiotic activity by Enterolobium contortisiliquum(Vell.)Morong
Asian Pacific Journal of Tropical Biomedicine
;
(12): 945-949, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-667502
ABSTRACT
Objective:
To identify the main chemical classes of compounds from aqueous extract of Enterolobium contortisiliquum (E. contortisiliquum) seed bark and to evaluate its anti-bacterial activity, as well as its potential to increase the activity of antibiotics against strains of Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli.Methods:
Different classes of compounds in the aqueous extract of E.contortisiliquum were evaluated based on the visual changes in the coloration and the formation of pre-cipitate after the addition of specific reagents.The antibacterial activity of the extract and its potential to increase of antibiotic activity of antibiotics drugs, gentamicin and nor-floxacin was determined by using the microdilution method.Results:
Our results demonstrated that the following secondary metabolites were pre-sented in E. contortisiliquum seed bark flavones, flavonols, xanthones, flavononols, chalcones, aurones,flavones and catechins. The extract itself had very low antibacterial activity against all bacterial strains tested (MIC ≥ 1 024 μg/mL), but there was an in-crease in the antibiotic activity of gentamicin and norfloxacin when combined in the sub-inhibitory concentration (i.e.,MIC/8).Conclusions:
Our data suggests that E.contortisiliquum seed bark may be an alternative source for new drugs with the potential to increase antibiotic activity against different strains of bacteria.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2017
Type:
Article
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