Research advances in the relationship between PARP-1 and its inhibitors and the development, progression,and radiosensitivity of tumors / 中华放射肿瘤学杂志

ABSTRACT

Poly(ADP-ribose)polymerase-1(PARP-1),a ubiquitous and abundant nuclear protein composed of amino-acid residues, plays an important role in the process of DNA damage repair. In recent years,some studies have confirmed that PARP-1 is closely related to the development and progression of tumors,and may influence the tumor radiosensitivity.This article summarizes the relationship of PARP-1 and its inhibitors and the development,progression,and radiosensitivity of tumors.