Clinical analysis of the etiology and severity of acute pancreatitis / 天津医药

ABSTRACT

Objective To investigate the relationship between the etiology and the severity of acute pancreatitis (AP). Methods The clinical data of 590 patients with AP who were admitted into our hospital from January 2007 to December 2016 were retrospectively analyzed. In these patients there were 459 patients with mild acute pancreatitis (MAP), 68 patients with moderate acute pancreatitis (MSAP) and 63 patients with severe acute pancreatitis (SAP). The relationship between the severity of disease and age, gender, etiologies and complications was analyzed. Results There were no significant differences in age, gender, and incidence rate of partial illness complication between three groups of patients. While the incidence rate of systemic complications was significantly higher in SAP group than that of other two groups ( P<0.05). In 590 patients, 352 patients (59.7%) were biliary pancreatitis, which was the first leading pathogenesis. There were 120 patienets (20.3%) were hyperlipidemic pancreatitis, which was the second pathogenesis. The incidence rate of hyperlipidemic AP was significantly higher in MSAP group and SAP group than those of MAP group, while the alcoholic AP was lower (P<0.05). A total of 7 cases (1.2%) of SAP were dead during hospitalization, and no patients were admitted to hospital for the second time due to AP during the follow ups (1 month after discharge). Conclusion Biliary pancreatitis is the primary pathogenesis of clinical acute pancreatitis, and its incidence rate of complication is higher. The obstruction of the biliary obstruction should be relieved as soon as possible to prevent the progression of the disease. Early diagnosis and symptomatic treatment can improve prognosis.